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Generic Nolvadex(Generic name: Tamoxifen Citrate)
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Nolvadex Overview |
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Nolvadex (generic name Tamoxifen Citrate) is a Women's Health medication.
Information about Nolvadex such as Nolvadex usage, Nolvadex side effects, detailed Nolvadex description and other you may find on our online pharmacy.
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brand name: Nolvadex
generic names: Tamoxifen, Tamoxifen citrate
How does it work? Nolvadex D tablets contain the active ingredient tamoxifen citrate, which is a type of medicine known as an 'anti-oestrogen'. (NB. Tamoxifen is also available without a brand name, ie as the generic medicine.) Tamoxifen is mainly used to treat women with breast cancers that respond to the female sex hormone, oestrogen.
Most breast cancers are sensitive to oestrogen, and their growth is increased in the presence of this hormone. Oestrogen binds to oestrogen receptors on the breast cancer cells and causes changes within the cells that result in faster growth of the cancer. Breast cancers that are sensitive to oestrogen are called oestrogen receptor positive cancers.
Tamoxifen works by blocking the oestrogen receptors, thereby blocking the effect of oestrogen on the cancer. This starves the breast cancer cells and stops them from growing.
Tamoxifen helps prevent breast cancer from spreading to other areas of the body and also reduces risk of developing cancer in the other breast.
Tamoxifen is also used in the treatment of female infertility that is caused by problems with ovulation. Again, it acts by blocking oestrogen receptors, this time in a part of the brain called the hypothalamus. The effect of this is an increase in the levels of the hormones that control the development and release of an egg. These hormones are released from the pituitary gland and are known as follicle stimulating hormone (FSH) and luteinising hormone (LH). FSH stimulates the ovaries and LH causes the release of an egg from the ovaries (ovulation).
In the normal menstrual cycle, oestrogen acts on receptors in the hypothalamus after ovulation. This causes the pituitary gland to stop releasing FSH and LH. As tamoxifen blocks the oestrogen receptors in the hypothalamus, it prevents this action of oestrogen. FSH and LH levels therefore increase, which increases the chances of egg development and ovulation.
Overdosage Any medication taken in excess can have serious consequences. If you suspect an overdose of Nolvadex (Tamoxifen), seek medical attention immediately. - Symptoms of Nolvadex (Tamoxifen) overdose may include:
Dizziness, tremor, overactive reflexes, unsteady gait
Overdosage Any medication taken in excess can have serious consequences. If you suspect an overdose of Nolvadex (Tamoxifen), seek medical attention immediately. - Symptoms of Nolvadex (Tamoxifen) overdose may include:
Dizziness, tremor, overactive reflexes, unsteady gait
How should I take this medicine?
Take tamoxifen tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. You may take tamoxifen with or without food. Take your doses at regular intervals. Do not stop taking except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
Warning! - Your doctor may want you to stop taking this medicine prior to any planned surgery or period of prolonged immobility. Discuss this with your doctor.
- Tamoxifen is associated with an increased risk of abnormal blood clots in the blood vessels (for example deep vein thrombosis or pulmonary embolism ), particularly during periods of immobilisation and following surgery. The benefits of taking tamoxifen to treat breast cancer outweigh this risk, pain on breathing or coughing, however you should consult your doctor immediately if you experience any of the following symptoms during treatment: stabbing pains and/or unusual swelling in one leg, sudden breathlessness or sudden severe chest pain. Consult your doctor for further information.
- Tamoxifen is associated with a small increase in the risk of endometrial cancer. The benefits of taking tamoxifen to treat breast cancer outweigh this risk, however, to minimise the risk you should consult your doctor if you experience any abnormal gynaecological symptoms during or after treatment, so that they can be investigated. Symptoms to report include vaginal bleeding, menstrual irregularities, vaginal discharge, or symptoms such as pelvic pain or pressure. Consult your doctor for further information.
- As this medicine may potentially cause harm to a developing baby, it should not be used during pregnancy. Women who have not yet passed the menopause should use a non-hormonal method of contraception to prevent pregnancy both during, and for two months following, treatment with this medicine.
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