Why is Depakote prescribed?

Depakote, in both delayed-release tablet and capsule form, is used to treat certain types of seizures and convulsions. It may be prescribed alone or with other epilepsy medications.

The delayed-release tablets are also used to control the manic episodes--periods of abnormally high spirits and energy--that occur in bipolar disorder (manic depression).

An extended-release form of this drug, Depakote ER, is prescribed to prevent migraine headaches. The delayed-release tablets are also used for this purpose.

Special warnings about Depakote (Divalproex)

This medication can severely damage the liver (see "Most important fact about this drug"). Your doctor will test your liver function before you begin taking this medication and at regular intervals thereafter.

Also remember that the drug can damage the pancreas (see "Most important fact about this drug"). This problem can worsen very rapidly, so be sure to contact your doctor immediately if you develop any symptoms.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Because Depakote (Divalproex) is often used with other antiseizure drugs, it may not be possible to determine whether a side effect is due to Depakote alone. Only your doctor can determine if it is safe for you to continue taking Depakote (Divalproex).

• More common side effects may include:
  Abdominal pain, weakness, vomiting, vision problems, tremor, sore throat, sleepiness, ringing in the ears, nervousness, nausea, nasal inflammation, memory loss, loss of appetite, insomnia, infection, indigestion, incoordination, headache, hair loss, flu symptoms, fever, emotional changeability, dizziness, diarrhea, depression, constipation, bruising, bronchitis, breathing difficulty, abnormal thinking, weight loss or gain

Why should Depakote (Divalproex) not be prescribed?

You should not take this medication if you have liver disease or your liver is not functioning well, or if you have a genetic abnormality known as urea cycle disorder (UCD).

If you are sensitive to or have ever had an allergic reaction to Depakote (Divalproex), you should not take this medication.

Special information if you are pregnant or breastfeeding

Depakote (Divalproex) may produce birth defects if it is taken during pregnancy. If you are pregnant or plan to become pregnant, inform your doctor immediately. Depakote appears in breast milk and could affect a nursing infant. If Depakote (Divalproex) is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.